PubMed Abstract PMID: 10355751
Full title: Expression and Its Possible Role in G1 Arrest and Apoptosis in Ellagic Acid Treated Cancer Cells
This abstract also posted in the files section of the K9Kitchen discussion group.

Monica's Comments
This study found that a specific concentration of Ellagic acid (found in fruits and nuts) slowed, stopped and reduced cervical cancers cells they tested. The study speculates about the mechanism that inhibits carcinogen-induced cancers.

The full study is posted as a PDF file at Science Direct for a $30 download.

The Abstract:
Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogen-induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.

Study Authors
Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW
Cancer Prevention Program, Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, USA

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