PubMed Abstract PMID: 14518142
Full title: Effect of Lactobacillus Strains and Saccharomyces Boulardii on Persistent Diarrhea in Children
This abstract also posted in the files section of the K9Kitchen discussion group.
Monica's Comments
This clinical trial asked if probiotics could be used to manage persistent
diarrhea in children. They tested Lactobacillus acidophillus and a couple
of other probiotic strains against a placebo test and found that each
of the probiotics significantly reduced the length and volume of both
diarrhea and vomiting.
Originally published in the Medicina, 2003.
The Abstract
The efficacy of probiotics on persistent diarrhea remains uncertain. The purpose of this study was to evaluate the effect of Lactobacillus sp and Saccharomyces boulardii on persistent diarrhea in children. In a double-blind trial eighty-nine children, aged 6-24 months were randomly distributed to receive pasteurized cow milk containing 2 viable lyophilized strains Lactobacillus casei and Lactobacillus acidophillus strains CERELA, (10(10)-10(12) colony-forming units per g) (n = 30), or lyophilized S. boulardii, (10(10)-10(12) colony forming units per g) (n = 30) or pasteurized cow milk as placebo (n = 29); on each diet 175 g was given twice a day for a 5 day period. Number of depositions, duration of illness and frequency of vomiting were considered. Enteric pathogens were isolated from stools in 40% of the patients, 27% had rotavirus. Lactobacillus and S. boulardii significantly reduced the number of depositions (p < 0.001) and diarrheal duration (p < 0.005). Similarly both significantly (p < 0.002) reduced vomiting as compared with placebo. There was no difference between treatments depending on rotavirus status. In conclusion, L. casei and L. acidophillus strains CERELA and S. boulardii are useful in the management of persistent diarrhea in children.
Study Authors
Gaon D, Garcia H, Winter L, Rodriguez N, Quintas R, Gonzalez SN, Oliver G.
Catedra de Salud Publica, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
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